Description
Methylprednisolone, a prednisolone derivative with similar anti-inflammatory action, is a corticosteroid medicine that prevents the release of substances in the body that cause inflammation.
Methylprednisolone is used to treat many different inflammatory conditions such as arthritis, lupus, psoriasis, ulcerative colitis, allergic disorders, gland (endocrine) disorders, and conditions that affect the skin, eyes, lungs, stomach, nervous system, or blood cells.
Methylprednisolone may also be used for purposes not listed in this medication guide.Adjunctive therapy for short-term administration in rheumatoid arthritis.
Pharmacodynamics
Methylprednisolone and its derivatives, methylprednisolone sodium succinate and methylprednisolone acetate, are synthetic glucocorticoids used as antiinflammatory or immunosuppressive agents.
Mechanism of action
Unbound glucocorticoids cross cell membranes and bind with high affinity to specific cytoplasmic receptors, modifying transcription and protein synthesis. By this mechanism, glucocorticoids can inhibit leukocyte infiltration at the site of inflammation, interfere with mediators of inflammatory response, and suppress humoral immune responses.
The antiinflammatory actions of corticosteroids are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes.
Side effects
All medicines may cause side effects, but many people have no, or minor, side effects.Some medical conditions may interact with Methylprednisolone.
Tell your doctor or pharmacist if you have any medical conditions.
Common methylprednisolone side effects may include: fluid retention (swelling in your hands or ankles), dizziness, spinning sensation, changes in your menstrual periods, headache, mild muscle pain or weakness or stomach discomfort, bloating.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider
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