Description
Tadalafil is an orally administered drug used to treat male erectile dysfunction (impotence). It is marketed worldwide under the brand name Cialis. It is a phosphodiesterase 5 (PDE5) inhibitor. Tadalafil’s distinguishing pharmacologic feature is its longer half-life (17.5 hours) compared with Viagra and Levitra (4-5 hours). This longer half-life results in a longer duration of action and is, in part, responsible for the Cialis nickname of the “weekend pill.”
Dapoxetine is a selective serotonin reuptake inhibitor, for the treatment of premature ejaculation. In a phase II proof-of-concept study conducted by PPD, dapoxetine demonstrated a statistically significant increase in ejaculatory latency when compared to placebo.
Tadapox is a combination drug that contains: Tadalafil at a dosage of 20 mg and 60 mg of Dapoxetine. Tadapox is manufactured by Rsm Enterprises in the form of classical round tablets of yellow color, packed in a blister of 10 pieces. This concentration is the maximum allowable dosage, which is not recommended to exceed. The medication is taken orally (with water) once a day, for 40-60 minutes before intimacy. The effect is observed after 30-40 minutes and lasts about 36-48 hours. Combine the use of Tadapox with alcoholic beverages, as this increases the risk of side effects.
Pharmacodynamics
Tadalafil is used to treat male erectile dysfunction (impotence) and pulmonary arterial hypertension (PAH). Part of the physiological process of erection involves the release of nitric oxide (NO) in the corpus cavernosum. This then activates the enzyme guanylate cyclase which results in increased levels of cyclic guanosine monophosphate (cGMP), leading to smooth muscle relaxation in the corpus cavernosum, resulting in increased inflow of blood and an erection. Tadalafil is a potent and selective inhibitor of cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum.
Dapoxetine is a selective serotonin reuptake inhibitor currently undergoing trials through Alza (under license from GenuPro, a collaboration between Eli Lilly and PPD). Dapoxetine is a short-acting SSRI drug currently being considered for approval by the Food and Drug Administration (FDA) for the treatment of premature ejaculation in men, which would make it the first drug approved for such treatment. Despite two clinical trials finished in 2006, experts doubt it will be approved by the FDA soon because SSRIs come with undesirable side-effects after long-term use, such as psychiatric problems, dermatological reactions, increase in body weight, lower sex-drive, nausea, headache, upset stomach and weakness, thus not significantly outweighing the benefit of premature ejaculation medication versus the risks.
Mechanism of Action
Tadalafil inhibits the cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum located around the penis. Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and corpus cavernosal smooth muscle. This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Cyclic GMP causes smooth muscle relaxation and increased blood flow into the corpus cavernosum. The inhibition of phosphodiesterase type 5 (PDE5) by tadalafil enhances erectile function by increasing the amount of cGMP.
Dapoxetine mechanism of action is thought to be related to inhibition of neuronal reuptake of serotonin and subsequent potentiation of serotonin activity. The central ejaculatory neural circuit comprises spinal and cerebral areas that form a highly interconnected network. The sympathetic, parasympathetic, and somatic spinal centers, under the influence of sensory genital and cerebral stimuli integrated and processed at the spinal cord level, act in synergy to command physiologic events occurring during ejaculation. Experimental evidence indicates that serotonin (5-HT), throughout brain descending pathways, exerts an inhibitory role on ejaculation.
Side effects
All medicines may cause side effects, but many people have no, or minor, side effects.Some medical conditions may interact with Tadalafil & Dapoxetine.
Tell your doctor or pharmacist if you have any medical conditions.
Common Tadalafil side effects may include: headache, flushing (warmth, redness, or tingly feeling), nausea, upset stomach, stuffy nose or muscle pain, back pain, pain in your arms or legs.
Common Dapoxetine side effects: feeling of warmth, fever, muscle aches, redness of the face, neck, arms, and occasionally, upper chest, sore throat, stuffy or runny nose.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.
zoritoler imol –
I’ve recently started a blog, the info you offer on this web site has helped me greatly. Thank you for all of your time & work.